Empty Capsids and Macrophage Inhibition/Depletion Increase rAAV Transgene Expression in Joints of Both Healthy and Arthritic Mice

Caroline J. Aalbers, Niels Broekstra, Mariska van Geldorp, Emiel Kramer, Sofia Ramiro, Paul P. Tak, Margriet J. Vervoordeldonk, and Jonathan D. Finn
The researchers present evidence demonstrating the synergistic enhancement of transgene expression achieved when the two pre-treatments were combined. read more

Intra-articular etanercept treatment in inflammatory arthritis:

A randomized double-blind placebo-controlled proof of mechanism clinical trial validating TNF as a potential therapeutic target for local treatment. read more

Preclinical Potency and Biodistribution Studies of an AAV 5 Vector

Expressing Human Interferon-β (ART-I02) for Local Treatment of Patients with Rheumatoid Arthritis. read more

Safety, Biodistribution, and Efficacy of an AAV-5 Vector Encoding Human Interferon-Beta (ART-I02)

Delivered via Intra-Articular Injection in Rhesus Monkeys with Collagen-Induced Arthritis. read more

Prevelance and pharmacological modulation of humoral immunity to AAV vectors in gene transfer to synovial tissue.

Mingozzi F, Chen Y, Edmonson SC, Zhou S , Thurlings RM, Tak PP, High KA, Vervoordeldonk MJ. Gene Therapy 2012 Jul 12. doi: 10.1038/gt.2012.55. [Epub ahead of print]

Advancements in adeno-associated viral gene therapy approaches: exploring a new horizon.

Aalbers CJ, Tak PP, Vervoordeldonk MJ. F1000 Med Rep. 2011;3:17. Epub 2011 Sep 1.

Animal models for arthritis: innovative tools for prevention and treatment.

Kollias G, Papadaki P, Apparailly F, Vervoordeldonk MJ, Holmdahl R, Baumans V, Desaintes C, Di Santo J, Distler J, Garside P, Hegen M, Huizinga TW, Jüngel A, Klareskog L, McInnes I, Ragoussis I, Schett G, Hart B, Tak PP, Toes R, van den Berg W, Wurst W, Gay S. Ann Rheum Dis. 2011 Aug;70(8):1357-62.

Evaluation of therapeutic targets in animal models of arthritis: how does it relate to rheumatoid arthritis?

Bevaart L, Vervoordeldonk MJ, Tak PP. Arthritis Rheum; 2010; 62(8):2192-205;

Adeno-associated virus type 5-mediated intraarticular administration of tumor necrosis factor small interfering RNA improves collagen-induced arthritis.

Khoury M, Courties G, Vervoordeldonk MJ, Tak PP, Jorgensen C, Apparailly F. Arthritis Rheum 2010;62(3):765-70.

Gene therapy targeting Nuclear Factor-κB: Towards Clinical Application in Inflammatory Diseases and Cancer.

Tas SW, Vervoordeldonk MJ, Tak PP. Current Gene Therapy 2009;9(3):160-70.Review

Interferonβ for rheumatoid arthritis: New clothes for an old kid on the block.

Vervoordeldonk MJ, Aalbers CJ, Tak PP. Editorial. Ann Rheum Dis. 2009;68(2):157-8.

Advances in local targeted gene therapy for arthritis: towards clinical reality.

Vervoordeldonk MJ, Aalbers CJ, Tak PP. Editorial; Future Rheumatology, 2008; 3 (4):307-309.

Inflammation-inducible anti-TNF gene expression mediated by intra-articular injection of serotype 5 AAV reduces arthritis.

Khoury M, Adriaansen J, Vervoordeldonk MJ, Gould D, Chernajovsky Y, Bigey P, Bloquel C, Sherman D, Tak PP, Jorgenson C, Apparailly F.. J Gene Med 2007; 9 (7):596-604.

Reduction of arthritis following intra-articular administration of an adeno-associated virus serotype 5 expressing a disease-inducible TNF-blocking agent.

Adriaansen J, Khoury M, de Cortie CJ, Fallaux FJ, Bigey P, Apparailly F, Jorgensen C, Vervoordeldonk MJ, Tak PP. Ann Rheum Dis 2007; 66(9):1143-1150.

Gene therapy for rheumatoid arthritis.

Vervoordeldonk MJ, Adriaansen J, Fallaux FJ, Tak PP. Anti-inflammatory and Anti-allergy Agents Med Chem 2007; 6: 109-120. Review

Local delivery of beta interferon using an adeno-associated virus type 5 effectively inhibits adjuvant arthritis in rats.

Adriaansen J, Fallaux FJ, de Cortie CJ, Vervoordeldonk MJ, Tak PP. J Gen Virol 2007; 88:1717-1721.

Intra-articular interferon-beta gene therapy ameliorates adjuvant arthritis in rats.

Adriaansen J, Kuhlman RR, van Holten J, Kaynor C, Vervoordeldonk MJ, Tak PP. Hum Gen Ther 2006;17: 985-996.

Amelioration of arthritis by intra-articular dominant negative IKKβ gene therapy using adeno-associated virus type 5.

Tas SW, Adriaansen J, Hajji N, Bakker AC, Firestein GS,Vervoordeldonk MJ, and Tak PP, Human Gene Therapy 2006;17:821–832.

Reduction of pro-inflammatory cytokine expression in the synovium by targeting inhibitor of nuclear factor (NF)-kB kinase β in vivo.

Tas SW, Stenvers DJ, Hajji N, Firestein GS, Vervoordeldonk MJ, and Tak PP. Arthr. Rheum. 2006; 54(11):3716-8.

Enhanced gene transfer to arthritic joints using adeno-associated virus type 5: implications for intraarticular gene therapy.

Adriaansen J, Tas SW, Klarenbeek PL, Bakker AC, Apparailly F, Firestein GS, Jorgensen C, Vervoordeldonk MJ, Tak PP, Ann Rheum.Dis.2005;64(12):1677-84.

Adeno-associated virus pseudotype 5 vector improve gene transfer in arthritic joints.

Apparailly F, Khoury M, Vervoordeldonk MJ, Adriaansen J, Gicquel E, Perez N, Riviere C, Louis-Plence P, Noel D, Douar A-M, Tak PP and Jorgensen C, Hum Gene Ther. 2005;16(4):426-34.

Gene therapy as therapeutic approach for the treatment of rheumatoid arthritis: innovative vectors and therapeutic genes.

Adriaansen J, MJ Vervoordeldonk, PP Tak. Rheumatology (Oxford) 2006; 45(6)656-68. Review